Such cells could be used as circulating carriers to disseminate a drug within a prolonged period of time in circulation or in targetspecific organs, including the liver, spleen, and lymph nodes. Hence, these carriers are called resealed erythrocytes. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Erythrocytes, the most abundant cells in the human body, have potential carrier capabilities for the delivery of drugs. Introduction definition and advantages formulation of sedds preparation of sedds mechanism of self emulsification in vitro evaluation of sedds improvement of oral absorption by sedds applications of sedds solid sedds recent approaches in sedds conclusion references download the powerpoint. Resealed erythrocytes as drug carriers pharmatutor. Free download red blood cells powerpoint presentation slides. The ringinfected erythrocyte surface antigen resa of. Resealed erythrocytes a specified tool in novel drug delivery system vaishali goel, charanjeet kaur, rainu devi, aman kumar, ujjwal nautiyal himachal institute of pharmacy, paonta sahib, distt. Resealed erythrocyte free download as powerpoint presentation. The total surface area on erythrocytes is proportional to 2000.
Red blood cells as smart delivery systems bioconjugate chemistry. Drugloaded erythrocytes can operate through one of the three main mechanisms of action. International journal of chemistry and pharmaceutical sciences. Mar 14, 2014 powerpoint is the worlds most popular presentation software which can let you create professional red blood cells powerpoint presentation easily and in no time. Seminar on resealed erythrocytes powerpoint ppt presentation. Photosensitizer decorated red blood cells as an ultrasensitive. Erythrocytes or the red blood cells are probably the most common cells found in the human body. College of pharmacy, teerthanker mahaveer university, moradabad, uttar pradesh, india erythrocytes have been the most interesting carrier and have found to possess great potential in drug targeting. Resealed erythrocyte based drug delivery system article pdf available in world journal of pharmacy and pharmaceutical sciences 62. Introduction basic concept of rbc drug carrying potential of rbc advantages and limitations source and isolation of rbc. The model of the erythrocyte membrane presented in cell biology, hematology, and biochemistry textbooks shows 2 major protein bridges that span between the phospholipid bilayer and the spectrinactin skeleton.
Evaluation n application of resealed erythrocytes 1. Appropriate size, shape to permit passage through the capillaries. So many drugs like aspirin, steroid, cancer drug which having many side effects are reduce by resealed erythrocyte. A cell that contains hemoglobin and can carry oxygen to the body.
Aug 27, 2009 analysis of the morphology of erythrocytes resealed in the presence of. Applications of resealed erythrocytes resealed erythrocytes have several possible applications in various fields of human and veterinary medicine. Red blood cells rbcs, also called erythrocytes, are the most abundant type of blood cells. Factors which considering resealed erythrocytes as carrier its shape and size to permit the passage through the capillaries. Ppt blood components powerpoint presentation free to.
The drug is entrapped in the erythrocytes, and resealing the resultant cellular carriers. Resealed erythrocytes as a carrier for drug targeting the pharma. Resealed erythrocyte red blood cell cell membrane free. As a member, youll also get unlimited access to over 79,000 lessons in math, english, science, history, and more. Have a browse through our large collection of free powerpoint templates, the most recent are shown first. Resealed erythrocytes, 5flurouracil, encapsulation, hypotonicpreswelling, isotonicresealing. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in. No difference was observed in the shape, size and drug content of loaded and lyophilized erythrocytes when compared with freshly loaded erythrocytes. Feb 11, 2016 drugloaded erythrocytes can operate through one of the three main mechanisms of action. Free red cells powerpoint template is a free medical powerpoint background and medical ppt template that you can download to prepare presentations on red cells and blood. Various bioactive agents encapsulated in erythrocytes are developed for the slow and sustained release in circulation to allow effective treatment of parasitic diseases. After long research, we found their intense application as a drug carrier in the drug delivery system.
Introduction various approaches to enhance efficacy of the drug hard and soft drugs prodrugs classification of prodrugs considerations in the design of prodrugs strategies in the design of prodrugs applications of prodrugs prodrug based novel drug delivery approaches conclusion references download the powerpoint by liking us on facebook. If you have an idea of what you want to find search by category and find the perfect powerpoint template to download for free. Resealed erythrocytes, drug carriers, drug loading, drug efficiency introduction resealed erythrocytes are most commonly known drug delivery system. Adhesion assays were performed using a gravity driven reverse suspension assay. They protect the premature degradation, inactivation and excretion of proteins and enzymes they can target the drugs within reticuloendothelial system they facilitate incorporation of proteins and nucleic acids in eukaryotic cells by cell infusion with rbc. Pdf resealed erythrocyte based drug delivery system. The latest free powerpoint templates from presentation. Institute of pharmaceutical sciences, udaipur rajasthan 301 erythrocytes, also known as red blood cells, have been extensively studied for their potential carrier capabilities for the delivery of drugs and drugloaded microspheres.
Further shelf life of drugloaded erythrocytes was prolonged by lyophilization. Oct 02, 20 resealed erythrocytes properties as carrier. Red blood cells, heamoglobin, resealed erythrocytes, heamolysis. The chemical constituent of red blood cells include water 63%, lipids 0. Mar 14, 2014 powerpoint is the worlds most popular presentation software which can let you create professional the red blood cell powerpoint presentation easily and in no time. This study was intended to develop an economical and simple method for transfection of p. Resealed erythrocytes as a carrier for drug targeting. Trafficking of the major virulence factor to the surface. Resealed erythrocytes serve as an ideal carrier for antineoplastic agents, antimicrobial drug and vitamins and steroids. The most abundant formed elements in blood, erythrocytes are red, biconcave disks packed with an oxygencarrying compound called hemoglobin. Lysereseal erythrocytes for transfection of plasmodium. Only redseal models your entire hybrid data center of public cloud, private cloud, and physical network so you can better prepare for and contain problems within minutes and not days.
Resealed erythrocytes a specified tool in novel drug delivery. Erythrocytes are flying saucer or discoid structures about 0. Jan, 2014 contents of the powerpoint on resealed erythrocytes include. Erythrocytes are biocompatible, biodegradable, possess very long circulation half lives and can be loaded with a variety of chemically and biologically active compounds using various. Although the clinical development of erythrocyte carriers is confronted with regulatory and development process challenges, industrial development is expanding.
In the bloodstream, iron picks up oxygen in the lungs and drops it off in the. For this assay, erythrocytes were resealed with different concentrations of gst, gst. You can also search for templates and backgrounds by category, popularity, colour or tag. The parameter indicates the effects of shear force and pressure by which resealed erythrocytes formulations are injected, on the integrity of the loaded cells.
Red blood cells rbcs have been widely explored as a natural drug. Resealed erythrocytes a specified tool in novel drug. The erythrocytes, which are heavy, will settle down to the bottom of the tube, while the plasma rises up to the top and the leukocytes and platelets will form a thin layer buffy coat between the erythrocytes and the plasma. Localization of glycolytic enzymes in murine erythrocytes resealed in the presence or absence of an antibody to the cytoplasmic domain of band 3. Characterization of human erythrocytes as potential carrier. Resealed erythrocytes are prepared by isolating erythrocytes from the plasma of the blood sample of an organism of interest, breakdown of cells using different methods and then entrapping the drug which is to be administered into the body into the erythrocytes by various techniques such as hypotonic haemolysis, hypotonic dilution, hypotonic. Red blood cells powerpoint template, backgrounds 02953. Ppt blood donation powerpoint presentation free to.
January, 2014 kiran kumar presentation comments off on ppt resealed erythrocytes ppt prodrugs ppt self emulsifying drug delivery systems sedds. Red blood cells have a characteristic pink appearance due to their high content of hemoglobin, which is basic. Presentation bypresentation by sunilboreddysunilboreddy m. Freshly drawn murine erythrocytes were washed 3 times to remove serum and buffy coat, and divided into 2 aliquots.
Winner of the standing ovation award for best powerpoint templates from presentations magazine. They appear as biconcave discs of uniform shape and size that lack organelles and granules. Erythrocytes, the most abundant cells in the human body, have. Erythrocytes, also known as red blood cells, and have been extensively studied for their potential carrier capabilities for the delivery of drugs. This protein is exported across the parasite plasma membrane and. C to reconstitute osmotic pressure and reseal those molecules inside rbcs. Free red blood cells powerpoint template can also be used as an original abstract powerpoint template to make presentations with original slide designs and red background.
Resealed erythrocytes are gaining more popularity because of their ability to circulate throughout the body, biocompatibility, zero order release kinetics, reproducibility and ease of preparation. This helps you give your presentation on red blood cells in a conference, a school lecture, a business proposal, in a webinar and business and professional representations the uploader spent hisher valuable time to create this. Contents of the powerpoint on self emulsifying drug delivery systems sedds include. Can be used to explain about blood cancer, low blood count, and other topics in medicine related to blood. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. This helps you give your presentation on red blood cells in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. L at 50% hct and then resealed for 45 minutes at 37c in pbs containing 4 mm mgcl 2. Source of erythrocytes different mammalian erythrocytes have been used for drug loading, resealing and subsequent. This helps you give your presentation on the red blood cell in a conference, a school lecture, a business proposal, in a webinar and business and professional representations the uploader spent hisher valuable time to. Most of the resealed erythrocytes used as drug carriers are rapidly taken up from blood by macrophages of reticuloendothelial system res, which is present in.
Resealed erythrocytes and monoclonal antibodies pp. Resealed erythrocytes are prepared by isolating erythrocytes from the plasma of the blood sample of an organism of interest, breakdown of cells using different methods and then entrapping the drug which is to be administered into the body into the erythrocytes by various techniques such as. Free download the red blood cell powerpoint presentation. Powerpoint is the worlds most popular presentation software which can let you create professional red blood cells powerpoint presentation easily and in no time. Resealed erythrocytes for drugloading carrier erythrocytes are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers5. Adhesive activity of lu glycoproteins is regulated by. Powerpoint is the worlds most popular presentation software which can let you create professional the red blood cell powerpoint presentation easily and in no time. The clear supernatant is analyzed for the drug content by spectroscopy method. Nov 01, 2008 localization of glycolytic enzymes in murine erythrocytes resealed in the presence of the cytoplasmic domain of murine band 3 residues 98. Jul 26, 2018 this tool does not provide medical advice. Erythrocytes are biconcave in shape, which increases the cells surface area and facilitates the diffusion of oxygen and carbon dioxide. Erythrocytes erythrocytes, or red blood cells, are the most ubiquitous cells in a blood smear.
Loaded erythrocytes 10% haematocrit, 5 ml are passed through a 23gauge hypodermic needle at a flow rate of 10 mlmin. The hemoglobin molecule contains four globin proteins bound to a pigment molecule called heme, which contains an ion of iron. Get the free download of all this pharmacy books download modern pharmaceutics by banker. Program for fundamental research fundamentals of the technology of. Adducin forms a bridge between the erythrocyte membrane. This helps you give your presentation on the red blood cell in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. Haematocrit value if blood is placed into a tube and centrifuged, the cells and the plasma will separate. This white paper provides an overview on the history and measurement of the erythrocyte sedimentation rate esr and the different testsinstruments available on the market. The resealed erythrocytes are biodegradable, biocompatible. It is intended for general informational purposes only and does not address individual circumstances. Contents of the powerpoint on resealed erythrocytes include. In normal conditions erythrocytes settle faster because they aggregate they form stacks called rouleaux. Introduction erythrocytes, the most abundant cells in the human. Free download the red blood cell powerpoint presentation slides.
The virulence protein p falciparum erythrocyte membrane protein 1 pfemp1 is responsible for cytoadherence of infected cells to host endothelial receptors. The ability of resealed erythrocyte to deliver drug to the liver or spleen can be viewed as a disadvantage is that other organs and tissues are inaccessible. This free blood cells powerpoint background contains blood cells images and is suitable for medicine presentations at classroom or hospitals. Adducin forms a bridge between the erythrocyte membrane and. Lyse reseal erythrocytes support efficient parasite growth. Plus, get practice tests, quizzes, and personalized coaching to help you succeed. International journal of chemistry and pharmaceutical sciences 169 and serves only to carry haemoglobin. This red powerpoint template with blood vessels and red blood cells will be a good illustration for presentation on erythrocytes, circulatory system, etc. Resealed erythrocytes, carriers, methods of drug loading. The rate of sedimentation of a single erythrocyte is 0.
Characterization of glycolytic enzyme interactions with. The erythrocyte is the presumptive target of some 400 p falciparum proteins, of which 225 are virulence proteins and 160 may be involved in erythrocyte remodeling. And because of this resealing process these carriers are called resealed erythrocytes. Drug loading in bodys own erythrocytes when used to serve as controlled delivery system. This work was partially supported by the national research programs from ministry of. Jan, 2014 contents of the powerpoint on prodrugs include.
Murine wildtype cdb3 was dialyzed against 5 mm of potassium phosphate containing 160 mm of sodium chloride, ph 7. Erythrocytes are biocompatible, biodegradable, possess long circulation half lives and can be loaded with a variety of biologica. After invading human red blood cells rbcs the malaria parasite plasmodium falciparum remodels the host cell by trafficking proteins to the rbc compartment. Explains about low white blood cell count, high red blood cells, red blood cell production, etc. The use of cells as drug delivery system requires that the drug which are normally unable to permeate the membrane, should be made to traverse the membrane without causing any irreversible changes in membrane structure and. It contains no nucleus and no organelles no dna and is stuffed with hemoglobin molecules. Resealed erythrocyte has got several advantages over the other drug delivery system which makes it superior than other systems. Hamidi m, zarrin a, foroozesh m, zarei n, mohammadisamani s. In vitro characterization of resealed erythrocytes drug content packed loaded erythrocytes 0. Preparation and in vitro evaluation of carrier erythrocytes for restargeted delivery of interferonalpha 2b. M were incubated for 1 hour on ice with leaky erythrocytes 500. It shows several publications on analysis of these tests in comparison with the gold standard of westergren and starrsed.